Occurrence of a Duodenal Polypoid Lesion During Long-Term Acid Suppression Therapy and Its Regression After Drug Discontinuation

Formation of multiple fundic gland polyps or hyperplastic in the gastric mucosa is one well-known adverse effects long-term acid suppression therapy for peptic ulcer disease. However, similar phenomenon has not been reported to occur duodenum. We report a case duodenal polypoid lesion that developed after use suppressants and disappeared cessation treatment. The patient was 76-year-old man with history heavy cigarette smoking excessive alcohol intake who had treated medication suppressants, including proton pump inhibitors potassium-competitive blockers, refractory gastroesophageal reflux After receiving 3 years, 10 mm diameter found at portion bulb. This 1.5 months hypothesized changes serum gastrin levels caused by might have associated development regression lesion.